Motivation / Pleasure Deficits, Not Expression Impairments, Contribute to Social Dysfunction in Schizophrenia Patients

Summary: Amotivation and anhedonia rather than expressive dysfunction play a critical role in determining social functioning in those with schizophrenia.

Source: Chinese Academy of Science

Schizophrenia is a complex neurodevelopmental and brain disorder associated with a wide range of psychopathology affecting cognition, emotion and thinking processes.

Although diagnosis of schizophrenia is mainly based on positive symptoms like hallucination and delusion, the ultimate functional outcome of patients with schizophrenia is mainly determined by negative symptoms such as anhedonia, amotivation and expressive dysfunctions.

However, the underlying relationship between negative symptoms and social functioning is not fully known.

Previous studies investigating the relationship between negative symptoms and social functioning adopted a unitary construct of negative symptoms. Recent findings support a two-factor model comprising amotivation / anhedonia and expression dysfunctions in schizophrenia. The unique impact of amotivation, anhedonia and expression upon social functioning needs further clarification.

In order to address this unclear issue, Dr. Raymond Chan and his team from the Institute of Psychology of the Chinese Academy of Sciences have adopted network analysis to specifically examine the network structure and interrelationship between negative symptoms (at both the “symptom-dimension” and “symptom-item” levels), other psychopathology and social functioning in 269 schizophrenia patients.

They assessed negative symptoms using the Clinical Assessment Interview for Negative Symptoms and the Positive and Negative Syndrome Scale, and social functioning using the Social and Occupational Functioning Assessment Scale.

Previous studies investigating the relationship between negative symptoms and social functioning adopted a unitary construct of negative symptoms. Image is in the public domain

According to the researchers, factor capturing anhedonia and amotivation was closely related to social functioning in schizophrenia patients, after controlling for medication side-effects, illness duration and other psychopathology. Consistent patterns of the network structure were shown at both “symptom-dimension” and “symptom-item” levels.

Subsequent analysis further showed that amotivation and anhedonia factor accounted for the largest proportion of variance of social functioning.

Taken together, these findings support that amotivation and anhedonia rather than expressive dysfunctions play a pivotal role in determining schizophrenia patients’ social functioning. This study highlights the amotivation and anhedonia as a potential intervention target for improving functional outcomes of schizophrenia patients.

Dr. Chan’s team is now investigating whether this pattern of relationship is unique to schizophrenia patients or shared by other psychiatric disorders exhibiting similar anhedonia, amotivation and expressive dysfunctions such as major depressive disorder and bipolar disorder.

About this schizophrenia research news

Author: Zhang Nannan
Source: Chinese Academy of Science
Contact: Zhang Nannan – Chinese Academy of Science
Image: The image is in the public domain

Original Research: Closed access.
“The Important Role of Motivation and Pleasure Deficits on Social Functioning in Patients With Schizophrenia: A Network Analysis” by Hui-xin Hu et al. Schizophrenia Bulletin


Abstract

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The Important Role of Motivation and Pleasure Deficits on Social Functioning in Patients With Schizophrenia: A Network Analysis

Negative symptoms, particularly the motivation and pleasure (MAP) deficits, are associated with impaired social functioning in patients with schizophrenia (SCZ). However, previous studies seldom examined the role of the MAP on social functioning while accounting for the complex interplay between other psychopathology.

This network analysis study examined the network structure and interrelationship between negative symptoms (at the “symptom-dimension” and “symptom-item” levels), other psychopathology and social functioning in a sample of 269 patients with SCZ. The psychopathological symptoms were assessed using the Clinical Assessment Interview for Negative Symptoms (CAINS) and the Positive and Negative Syndrome Scale (PANSS).

Social functioning was evaluated using the Social and Occupational Functioning Assessment Scale (SOFAS). Centrality indices and relative importance of each node were estimated. The network structures between male and female participants were compared.

Our resultant networks at both the “symptom-dimension” and the “symptom-item” levels suggested that the MAP factor / its individual items were closely related to social functioning in SCZ patients, after controlling for the complex interplay between other nodes.

Relative importance analysis showed that MAP factor accounted for the largest proportion of variance of social functioning. This study is among the few which used network analysis and the CAINS to examine the interrelationship between negative symptoms and social functioning.

Our findings supported the pivotal role of the MAP factor to determine SCZ patients’ social functioning, and as a potential intervention target for improving functional outcomes of SCZ.

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